17/03/2017
European Research Council

Post-doctoral Fellowship Position in Biophysics & Imaging


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    Biological sciencesBiology
    PhysicsBiophysics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    17/04/2017 21:00 - Europe/Brussels
  • LOCATION
    France › Marseille
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/09/2017
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC

The team “Physical and Molecular Principles governing Cytoskeletal Organization” (http://www.ibdm.univ-mrs.fr/equipe/physical-and-molecular-principles-governing-cytoskeletal-organization/) wishes to recruit a post-doc in Marseilles on a project funded by the ERC (European Research Council).

Actin filaments are key components of the cytoskeleton, and their assembly into various complex tridimensional networks serves as an internal architecture for eukaryotic cells. The fast dynamics of these polymeric networks enable cells to exert forces in order to change their shape, move, and divide themselves.

Our team studies the physical and molecular rules regulating actin assembly into different networks. To that end, we develop diverse techniques in order to understand how actin-regulating proteins cooperate with actin in a complex environment. We mostly use in vitro approaches, using purified proteins or cellular protein extracts, combined with top-end fluorescence imaging techniques. For example, the image on the right represents the nucleation and branching of individual actin filaments by the Arp2/3 complex.

How cells organize their interior is one of the central questions in biology. The objective of this specific project is to understand the molecular mechanisms that cells use to segregate actin-regulating proteins from a common pool of components. The candidate will have to identify and characterize some of the involved molecular players, using molecular imaging and modeling.

We are looking for a PhD doctor with a background in physics and/or chemistry. This is an interdisciplinary project and the candidate should be willing to acquire new skills to complete his profile. The candidate should be autonomous and capable of finding the required information in the neighboring labs or in the literature. Interactions with all other lab members are fundamental in the way we work in the institute. He/she will have to be creative while being highly rigorous. Finally, the capacity to provide a comprehensive and synthetic description of ongoing work will be required.

Our team is hosted at the Institut de Biologie du Développement in Marseilles. This institute offers exceptional working conditions, including an international atmosphere and world-class facilities. Speaking french is not required.

References: 1. GRESSIN L, GUILLOTIN A, GUERIN C, BLANCHOIN L, MICHELOT A. Architecture Dependence of Actin Filament Network Disassembly. Curr Biol. 2015 Jun 1;25(11):1437-47.

2. MICHELOT A, DRUBIN DG. Building Distinct Actin Filament Networks in a Common Cytoplasm. Curr Biol. 2011 Jul 26;21(14):R560-9

Starting date: Fall 2017.

Salary will depend on candidate diploma and experience

Application:

- Detailed CV

- 2+ references

- Letter of motivation

Please e-mail to alphee.michelot@univ-amu.fr

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Physics: PhD or equivalent
    Biological sciences: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

We are looking for a PhD doctor with a background in physics and/or chemistry. This is an interdisciplinary project and the candidate should be willing to acquire new skills to complete his profile. The candidate should be autonomous and capable of finding the required information in the neighboring labs or in the literature. Interactions with all other lab members are fundamental in the way we work in the institute. He/she will have to be creative while being highly rigorous. Finally, the capacity to provide a comprehensive and synthetic description of ongoing work will be required.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 offer(s) available at
Institut de Biologie du Développement de Marseille
France
Marseille
13288

EURAXESS offer ID: 191988